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Development of C-11 and F-18 PET tracers for neuroimaging

Author: Jeff Stehouwer

Development of C-11 and F-18 PET tracers for imaging the serotonin and dopamine transporters.

MicroPET images obtained by injection of [11C]mZIENT into an anesthetized cynomolgus monkey. HRRT images obtained by injection of [18F]FEmZIENT into an awake rhesus monkey.
MicroPET images obtained by injection of [11C]mZIENT into an anesthetized cynomolgus monkey.

HRRT images obtained by injection of [18F]FEmZIENT into an awake rhesus monkey.
HRRT images obtained by injection of [18F]FBFNT into an awake rhesus monkey.
HRRT images obtained by injection of [18F]FBFNT into an awake rhesus monkey.

MicroPET baseline time-activity curve obtained by injection of [18F]FEmZIENT into an anesthetized cynomolgus monkey.
MicroPET baseline time-activity curve obtained by injection of [18F]FEmZIENT into an anesthetized cynomolgus monkey.
HRRT baseline time-activity curve obtained by injection of [18F]FBFNT into an awake rhesus monkey.
HRRT baseline time-activity curve obtained by injection of [18F]FBFNT into an awake rhesus monkey.

Project Team

Jeff Stehouwer, PhD, Mark Goodman, PhD, Ron Voll, PhD, Vernon (Mel) Camp, Larry Williams, Mike Owens, PhD, John Votaw, PhD, Leonard Howell, PhD