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Publications

Selected publications in this area:


1. Jarkas N, McConathy J, Votaw JR, Voll RJ, Malveaux E, Camp VM, Williams L, Goodman RR, Kilts CD, Goodman MM. Synthesis and characterization of EADAM: a selective radioligand for mapping the brain serotonin transporters by positron emission tomography. Nucl Med Biol. 2005 Jan;32(1):75-86. PubMed PMID: 15691664.

2. Jarkas N, McConathy J, Voll RJ, Goodman MM. Synthesis, in vitro characterization, and radiolabeling of N,N-dimethyl-2-(2'-amino-4'-substituted-phenylthio)benzylamines: potential candidates as selective serotonin transporter radioligands. J Med Chem. 2005 Jun 30;48(13):4254-65. PubMed PMID: 15974579.

3. Jarkas N, Voll RJ, Williams L, Votaw JR, Owens M, Goodman MM. Synthesis and in vivo evaluation of halogenated N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine derivatives as
PET serotonin transporter ligands
. J Med Chem. 2008 Jan 24;51(2):271-81. Epub 2007 Dec 18. PubMed PMID: 18085744.

4. Jarkas N, Voll RJ, Williams L, Goodman MM. Validation of two fluoro-analogues of N,N-dimethyl-2-(2'-amino-4'-hydroxymethyl-phenylthio)benzylamine as serotonin transporter imaging agents using microPET. Nucl Med Biol. 2010 Jul;37(5):593-603. PubMed PMID: 20610164.

5. Jarkas N, Votaw JR, Voll RJ, Williams L, Camp VM, Owens MJ, Purselle DC, Bremner JD, Kilts CD, Nemeroff CB, Goodman MM. Carbon-11 HOMADAM: a novel PET radiotracer for imaging serotonin transporters. Nucl Med Biol. 2005 Apr;32(3):211-24. PubMed PMID: 15820756.

6. Stehouwer JS, Plisson C, Jarkas N, Zeng F, Voll RJ, Williams L, Martarello L, Votaw JR, Tamagnan G, Goodman MM. Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 (N-fluoroalkyl) labeled 2beta-carbomethoxy-3beta-(4'-(3-furyl)phenyl)tropanes and -nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. J Med Chem. 2005 Nov 3;48(22):7080-3. PubMed PMID: 16250668.

7. Plisson C, Jarkas N, McConathy J, Voll RJ, Votaw J, Williams L, Howell LL, Kilts CD, Goodman MM. Evaluation of carbon-11-labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane as a potential radioligand for imaging the serotonin transporter by PET. J Med Chem. 2006 Feb 9;49(3):942-6. PubMed PMID: 16451060.

8. Zeng F, Jarkas N, Owens MJ, Kilts CD, Nemeroff CB, Goodman MM. Synthesis and monoamine transporter affinity of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-position. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4661-3. Epub 2006 Jun 19. PubMed PMID: 16784855.

9. Tamagnan GD, Brenner E, Alagille D, Staley JK, Haile C, Koren A, Early M, Baldwin RM, Tarazi FI, Baldessarini RJ, Jarkas N, Goodman MM, Seibyl JP. Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER. Bioorg Med Chem Lett. 2007 Jan 15;17(2):533-7. Epub 2006 Oct 12. PubMed PMID: 17095215; PubMed Central PMCID: PMC1806685.

10. Stehouwer JS, Jarkas N, Zeng F, Voll RJ, Williams L, Owens MJ, Votaw JR, Goodman MM. Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. J Med Chem. 2006 Nov 16;49(23):6760-7. PubMed PMID:
17154506.

11. McConathy J, Capello C, Jarkas N, Stowe ZN, Owens MJ. Preparation of antidepressants for use in preclinical research. Int J Neuropsychopharmacol. 2007 Dec;10(6):759-63. Epub 2007 Jan 4. PubMed PMID: 17201995.

12. Zeng F, Stehouwer JS, Jarkas N, Voll RJ, Williams L, Camp VM, Votaw JR, Owens MJ, Kilts CD, Nemeroff CB, Goodman MM. Synthesis and biological evaluation of 2beta,3alpha-(substituted phenyl)nortropanes as potential norepinephrine transporter imaging agents. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3044-7. Epub 2007 Mar 23. PubMed PMID: 17446069.

13. Zeng F, Jarkas N, Stehouwer JS, Voll RJ, Owens MJ, Kilts CD, Nemeroff CB, Goodman MM. Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter. Bioorg Med Chem. 2008 Jan 15;16(2):783-93. Epub 2007 Oct 13. PubMed PMID: 17983754.

14. Nye JA, Votaw JR, Jarkas N, Purselle D, Camp V, Bremner JD, Kilts CD, Nemeroff CB, Goodman MM. Compartmental modeling of 11C-HOMADAM binding to the serotonin transporter in the healthy human brain. J Nucl Med. 2008 Dec;49(12):2018-25. PubMed PMID: 19038997.

15. Stehouwer JS, Jarkas N, Zeng F, Voll RJ, Williams L, Camp VM, Malveaux EJ, Votaw JR, Howell L, Owens MJ, Goodman MM. Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. J Med Chem. 2008 Dec 25;51(24):7788-99. PubMed PMID: 19053782; PubMed Central PMCID: PMC2668213.

16. Zeng F, Mun J, Jarkas N, Stehouwer JS, Voll RJ, Tamagnan GD, Howell L, Votaw JR, Kilts CD, Nemeroff CB, Goodman MM. Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 labeled reboxetine analogues: potential positron emission tomography radioligands for in vivo imaging of the norepinephrine transporter. J Med Chem. 2009 Jan 8;52(1):62-73. PubMed PMID: 19067522; PubMed Central PMCID: PMC2746395.

17. Jarkas N, Voll RJ, Williams L, Camp VM, Goodman MM. (R,S)-anti-1-amino-2-[18F]fluorocyclopentyl-1-carboxylic acid: synthesis from racemic 2-benzyloxycyclopentanone and biological evaluation for brain tumor imaging with positron emission tomography. J Med Chem. 2010 Sep 23;53(18):6603-7. PubMed PMID: 20718421.

18. Yu W, Williams L, Malveaux E, Camp VM, Olson JJ, Goodman MM. Synthesis and evaluation of [123I] labeled iodovinyl amino acids syn-, anti-1-amino-3-[2-iodoethenyl]-cyclobutane-1-carboxylic acid, and
1-amino-3-iodomethylene-cyclobutane-1-carboxylic acid as potential SPECT brain tumor imaging agents
. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1264-8. Epub 2008 Jan 13. PubMed PMID: 18258425; PubMed Central PMCID: PMC2362394.

19. Yu W, Williams L, Camp VM, Malveaux E, Olson JJ, Goodman MM. Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent. Bioorg Med Chem. 2009 Mar 1;17(5):1982-90. Epub 2009 Jan 21. PubMed PMID: 19216081.

20. Yu W, McConathy J, Williams L, Camp VM, Malveaux EJ, Zhang Z, Olson JJ, Goodman MM. Synthesis, radiolabeling, and biological evaluation of (R)- and (S)-2-amino-3-[(18)F]fluoro-2-methylpropanoic acid (FAMP) and (R)- and (S)-3-[(18)F]fluoro-2-methyl-2-N-(methylamino)propanoic acid (NMeFAMP) as potential PET radioligands for imaging brain tumors. J Med Chem. 2010 Jan 28;53(2):876-86. PubMed PMID: 20028004; PubMed Central PMCID: PMC2836592.

21. Yu W, Williams L, Camp VM, Olson JJ, Goodman MM. Synthesis and biological evaluation of anti-1-amino-2-[18F]fluoro-cyclobutyl-1-carboxylic acid (anti-2-[18F]FACBC) in rat 9L gliosarcoma. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2140-3. Epub 2010 Feb 14. PubMed PMID: 20207538.

22. Savir-Baruch B, Schuster DM, Jarkas N, Master VA, Nieh PT, Halkar RK, Nye JA, Lewis MM, Crowe RJ, Voll RJ, Camp VM, Bellamy LM, Roberts DL, Goodman MM. Pilot Evaluation of Anti-1-amino-2-[(18)F] fluorocyclopentane-1-carboxylic acid (anti-2-[(18)F] FACPC) PET-CT in Recurrent Prostate Carcinoma. Mol Imaging Biol. 2010 Oct 26. [Epub ahead of print] PubMed PMID: 20976627; PubMed Central PMCID:
PMC3139806.

23. Kimmel HL, Negus SS, Wilcox KM, Ewing SB, Stehouwer J, Goodman MM, Votaw JR, Mello NK, Carroll FI, Howell LL. Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys. Pharmacol Biochem Behav. 2008 Sep;90(3):453-62. Epub 2008 Apr 4. PubMed PMID: 18468667; PubMed Central PMCID: PMC2453312.

24. Yu W, Wang E, Voll RJ, Miller AH, Goodman MM. Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as
potential PET radioligands for imaging peripheral benzodiazepine receptor
. Bioorg Med Chem. 2008 Jun 1;16(11):6145-55. Epub 2008 Apr 25. PubMed PMID: 18472268.

25. Mun J, Wang Y, Voll RJ, Escuin-Borras D, Giannakakou P, Goodman MM. Syntheses and biological activities of novel 2-methoxyestradiol analogs, 2-fluoroethoxyestradiol and 2-fluoropropanoxyestradiol, and a radiosynthesis of 2-[(18)F]fluoroethoxyestradiol for positron emission tomography. Nucl Med Biol. 2008 Jul;35(5):615-22. PubMed PMID: 18589306; PubMed Central PMCID: PMC2652255.

26. McConathy J, Goodman MM. Non-natural amino acids for tumor imaging using positron emission tomography and single photon emission computed tomography. Cancer Metastasis Rev. 2008 Dec;27(4):555-73. Review. PubMed PMID: 18648909.

27. Fantegrossi WE, Bauzo RM, Manvich DM, Morales JC, Votaw JR, Goodman MM, Howell LL. Role of dopamine transporters in the behavioral effects of 3,4-methylenedioxymethamphetamine (MDMA) in nonhuman primates. Psychopharmacology (Berl). 2009 Aug;205(2):337-47. Epub 2009 May 7. PubMed PMID: 19421742.

28. Schuster DM, Nye JA, Nieh PT, Votaw JR, Halkar RK, Issa MM, Yu W, Sepulveda J, Zeng W, Young A, Goodman MM. Initial experience with the radiotracer anti-1-amino-3-[18F]Fluorocyclobutane-1-carboxylic acid (anti-[ 18F]FACBC) with PET in renal carcinoma. Mol Imaging Biol. 2009 Nov-Dec;11(6):434-8. Epub 2009 May 16. PubMed PMID: 19449079.

29. Howell LL, Votaw JR, Goodman MM, Lindsey KP. Cortical activation during cocaine use and extinction in rhesus monkeys. Psychopharmacology (Berl). 2010 Feb;208(2):191-9. Epub 2009 Nov 19. PubMed PMID: 19924404; PubMed Central PMCID: PMC2819208.

30. Stehouwer JS, Goodman MM. Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine. PET Clin. 2009 Jan;4(1):101-128. PubMed PMID: 20216936; PubMed Central PMCID: PMC2834529.

31. Stehouwer JS, Daniel LM, Chen P, Voll RJ, Williams L, Plott SJ, Votaw JR, Owens MJ, Howell L, Goodman MM. Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomography. J Med Chem. 2010 Aug 12;53(15):5549-57. PubMed PMID: 20597489.

32. Cosgrove KP, Staley JK, Baldwin RM, Bois F, Plisson C, Al-Tikriti MS, Seibyl JP, Goodman MM, Tamagnan GD. SPECT imaging with the serotonin transporter radiotracer [123I]p ZIENT in nonhuman primate brain. Nucl Med Biol. 2010 Jul;37(5):587-91. Epub 2010 May 6. PubMed PMID: 20610163; PubMed Central PMCID: PMC2901233.

33. Schuster DM, Savir-Baruch B, Nieh PT, Master VA, Halkar RK, Rossi PJ, Lewis MM, Nye JA, Yu W, Bowman FD, Goodman MM. Detection of recurrent prostate carcinoma with anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid PET/CT and 111In-capromab pendetide SPECT/CT. Radiology. 2011 Jun;259(3):852-61. Epub 2011 Apr 14. PubMed PMID: 21493787; PubMed Central PMCID: PMC3099047.

34. Howell LL, Carroll FI, Votaw JR, Goodman MM, Kimmel HL. Effects of combined dopamine and serotonin transporter inhibitors on cocaine self-administration in rhesus monkeys. J Pharmacol Exp Ther. 2007 Feb;320(2):757-65. Epub 2006 Nov 14.PubMed PMID: 17105829.

35. Oka S, Hattori R, Kurosaki F, Toyama M, Williams LA, Yu W, Votaw JR, Yoshida Y, Goodman MM, Ito O. A preliminary study of anti-1-amino-3-18F-fluorocyclobutyl-1-carboxylic acid for the detection of prostate cancer. J Nucl Med. 2007 Jan;48(1):46-55. PubMed PMID: 17204698.

36. Schuster DM, Votaw JR, Nieh PT, Yu W, Nye JA, Master V, Bowman FD, Issa MM, Goodman MM. Initial experience with the radiotracer anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid with PET/CT in prostate carcinoma. J Nucl Med. 2007 Jan;48(1):56-63. PubMed PMID: 17204699.

37. Nye JA, Schuster DM, Yu W, Camp VM, Goodman MM, Votaw JR. Biodistribution and radiation dosimetry of the synthetic nonmetabolized amino acid analogue anti-18F-FACBC in humans. J Nucl Med. 2007 Jun;48(6):1017-20. Epub 2007 May 15. PubMed PMID: 17504867.

38. Yoon Y, Liang Z, Zhang X, Choe M, Zhu A, Cho HT, Shin DM, Goodman MM, Chen ZG, Shim H. CXC chemokine receptor-4 antagonist blocks both growth of primary tumor and metastasis of head and neck cancer in xenograft mouse models. Cancer Res. 2007 Aug 1;67(15):7518-24. PubMed PMID: 17671223.

39. Plisson C, Stehouwer JS, Voll RJ, Howell L, Votaw JR, Owens MJ, Goodman MM. Synthesis and in vivo evaluation of fluorine-18 and iodine-123 labeled 2beta-carbo(2-fluoroethoxy)-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane as a candidate serotonin transporter imaging agent. J Med Chem. 2007 Sep 20;50(19):4553-60. Epub 2007 Aug 17. PubMed PMID: 17705359.

40. Yu W, McConathy J, Olson J, Camp VM, Goodman MM. Facile stereospecific synthesis and biological evaluation of (S)- and (R)-2-amino-2-methyl-4-[123I]iodo-3-(E)-butenoic acid for brain tumor imaging
with single photon emission computerized tomography
. J Med Chem. 2007 Dec 27;50(26):6718-21. Epub 2007 Dec 4. PubMed PMID: 18052089.

41. Voll RJ, McConathy J, Waldrep MS, Crowe RJ, Goodman MM. Semi-automated preparation of the dopamine transporter ligand [(18)F]FECNT for human PET imaging studies. Appl Radiat Isot. 2005 Sep;63(3):353-61. PubMed PMID: 15985372.

42. Stehouwer JS, Chopra A. N-((E)-4-[18F]Fluorobut-2-en-1-yl)-2β-carbomethoxy-3β-(4'-fluorophenyl)nortropane. 2011 Jan 31 [updated 2011 Mar 31]. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2011. Available from http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=micad&part=FBFNT18F PubMed PMID: 21473033.

43. Zeng F, Southerland JA, Voll RJ, Votaw JR, Williams L, Ciliax BJ, Levey AI, Goodman MM. Synthesis and evaluation of two 18F-labeled imidazo[1,2-a]pyridine analogues as potential agents for imaging beta-amyloid in Alzheimer's disease. Bioorg Med Chem Lett. 2006 Jun 1;16(11):3015-8. Epub 2006 Mar 29. PubMed PMID:16574411.

44. Cappelli A, Mancini A, Sudati F, Valenti S, Anzini M, Belloli S, Moresco RM, Matarrese M, Vaghi M, Fabro A, Fazio F, Vomero S. Synthesis and biological characterization of novel 2-quinolinecarboxamide ligands of the peripheral benzodiazepine receptors bearing technetium-99m or rhenium. Bioconjug Chem. 2008 Jun;19(6):1143-53. Epub 2008 May 30. PubMed PMID: 18510350.

45. Anzini M, Chelini A, Mancini A, Cappelli A, Frosini M, Ricci L, Valoti M, Magistretti J, Castelli L, Giordani A, Makovec F, Vomero S. Synthesis and biological evaluation of amidine, guanidine, and thiourea derivatives of 2-amino(6-trifluoromethoxy)benzothiazole as neuroprotective agents potentially useful in brain diseases. J Med Chem. 2010 Jan 28;53(2):734-44. PubMed PMID:19950903.

46. Tan X, Sidell N, Mancini A, Huang RP, Shenming Wang, Horowitz IR, Liotta DC, Taylor RN, Wieser F. Multiple anticancer activities of EF24, a novel curcumin analog, on human ovarian carcinoma cells. Reprod Sci. 2010 Oct;17(10):931-40. Epub 2010 Aug 6. PubMed PMID: 20693500.

47. Cappelli A, Valenti S, Mancini A, Giuliani G, Anzini M, Altieri S, Bortolussi S, Ferrari C, Clerici AM, Zonta C, Carraro F, Filippi I, Giorgi G, Donati A, Ristori S, Vomero S, Concas A, Biggio G. Carborane-conjugated
2-quinolinecarboxamide ligands of the translocator protein for boron neutron capture therapy
. Bioconjug Chem. 2010 Dec 15;21(12):2213-21. Epub 2010 Nov 18.PubMed PMID: 21087014.

48. Masilamoni G, Votaw J, Howell L, Villalba RM, Goodman M, Voll RJ, Stehouwer J, Wichmann T, Smith Y. (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonism. Exp Neurol. 2010 Dec;226(2):265-73. Epub 2010 Sep 9. PubMed PMID: 20832405.

49. Votaw J, Byas-Smith M, Hua J, Voll R, Martarello L, Levey AI, Bowman FD, Goodman M. Interaction of isoflurane with the dopamine transporter. Anesthesiology. 2003 Feb;98(2):404-11. PubMed PMID: 12552200.

50. Davis MR, Votaw JR, Bremner JD, Byas-Smith MG, Faber TL, Voll RJ, Hoffman JM, Grafton ST, Kilts CD, Goodman MM. Initial human PET imaging studies with the dopamine transporter ligand 18F-FECNT. J Nucl Med. 2003 Jun;44(6):855-61. PubMed PMID: 12791810.

51. McConathy J, Voll RJ, Yu W, Crowe RJ, Goodman MM. Improved synthesis of anti-[18F]FACBC: improved preparation of labeling precursor and automated radiosynthesis. Appl Radiat Isot. 2003 Jun;58(6):657-66. PubMed PMID: 12798374.

52. Byas-Smith M, Votaw J, Hua J, Voll R, Martarello L, Levey AI, Goodman M. Phenylephrine and norepinephrine increase dopamine transporter ligand binding in striatum. Mol Imaging Biol. 2003 Jul-Aug;5(4):217-26. PubMed PMID: 14499136.

53. Votaw JR, Byas-Smith MG, Voll R, Halkar R, Goodman MM. Isoflurane alters the amount of dopamine transporter expressed on the plasma membrane in humans.Anesthesiology. 2004 Nov;101(5):1128-35. PubMed PMID: 15505448.